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What Does Sign Up Now Mean?
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Despite the fact that a shared attribute of DNA ligases is their envelopment of the nicked duplex as a C-formed protein clamp, they carry out this feat by making use of remarkably distinctive accent structural modules and domain topologies. As structural, biochemical, and phylogenetic insights coalesce, we can easily be expecting advancements on numerous fronts, like (i) pharmacological targeting of ligases for antibacterial and anticancer therapies and (ii) the discovery and design of recent strand-sealing enzymes with exceptional substrate specificities.
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), which is similar angular posture because the covalent connections involving the ChVLig OB domain and the strands in the latch. Hence, Character has uncovered very diverse structural solutions to the problem of DNA envelopment by ATP-dependent ligases.
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, shown are superimposed structures of NAD+ and the pyridopyrimidine inhibitor of their respective LigA complexes.
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